Portland Press, the knowledge hub for the molecular life sciences, publishes articles covering many aspects of drug discovery, from structure-based drug discovery, chemical biology and small-molecule inhibitors to targeted delivery of therapeutics for disease management.
Highlighting the top papers published across the Portland Press journals this year - including some of the top cited novel research papers, highly accessed articles, and top quality reviews from key opinion leaders!
This collection highlights papers published in the Portland Press publishing portfolio in the area of neuroscience, to coincide with the Society for Neuroscience Annual Meeting being held in Chicago 17-21 October 2015.
It has been estimated that approximately 30% of current R&D spend in pharmaceutical companies is focused on the development of kinase inhibitors. In the field of cancer, protein kinases have become the pharmaceutical industry’s most important class of drug target. To date, about 25 drugs targeting protein kinases have been clinically approved for use in cancer. FDA approval of a JAK3 inhibitor for the treatment of rheumatoid arthritis shows that the therapeutic use of kinase inhibitors is not limited to the acute treatment of cancer. There are over 100 small-molecule kinase inhibitors active in clinical development and many more are likely to be FDA approved in the coming years. Consequently, there is likely to be a continuing interest to better understand the roles that protein kinases play in human diseases in the foreseeable future. This collection highlights recent research and review articles from across the Portland Press portfolio exploring the regulation and function of protein kinases in cancer, inflammation and metabolism.
October is National Breast Cancer Awareness Month and to co-incide with this annual campaign, we have put together a collection of recent top quality research and review articles exploring the mechanisms involved in the development and treatment of breast cancer.
The 6th Annual EMBO meeting took place in Birmingham, UK in September 2015 to promote the life sciences and the exchange of scientific results. The meeting encourages scientists to look beyond their own fields, engage with the international scientific community and explore interdisciplinary approaches to research in the life sciences. Topics covered the entire range of the life sciences – from studies of molecules and the cell all the way up to investigation of larger, complex biological systems. To coincide with this meeting, Portland Press highlights a collection of recent papers from across our portfolio of journals.
August 2015 saw the joint meeting of the 23rd Congress of the International Union for Biochemistry and Molecular Biology (IUBMB) and the 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq) in Brazil. Symposia covered topics including protein structure and folding; stem cells; bioenergetics; redox signalling; and cell signalling. To coincide with this meeting, Portland Press highlights a collection of recent papers.
This meeting brought together both world leading and early career scientists to discuss their latest research into the cellular functions of inositol phospholipids and phosphates. To coincide with this joint Biochemical Society / FEBS Focused Meeting that was held as a commemoration of the retirement of Professor Robin Irvine FRS, Portland Press presents this collection of papers from across our journals. Topics covered include inositol signalling, including a paper from from Professor Irvine.
Also available from Portland Press and first published in the early 2000s, Cell Signalling Biology is an outstanding online resource describing the biology of cell signalling, written by Professor Sir Michael Berridge. The resource contains must-know information on each signalling pathway that is condensed into a concise and clear format via cell signalling maps, with illustrations of how biological processes are regulated and explanations of how disruptions in control pathways cause human diseases. Over 150 cell signalling pathways are outlined across the 12 'modules'. This resource is freely available to all, and is especially relevant to researchers, teachers and students in the cellular life sciences.
This Collection celebrates the recent publication of Essays in Biochemistry: Membrane Nanodomains and illustrates that membrane domains have roles in areas including cell signalling, protein sorting and vesicular trafficking. The Essays volume includes insights from many different research disciplines, from theoretical physics to experimental biology, and this corresponding collection covers a wide range of topics and techniques, including lipid distribution in the membrane, lipid rafts & nanodomains, cellular energy, crystallisation, cell signalling and cell regulation.
This meeting was held at the University of Aberdeen in July 2015.Sponsored by the Biochemical Society, the meeting included a range of presentations from across the full breadth of translation and RNA biology and in celebration we have selected some related articles you might find interesting.
The 40th FEBS Congress explored “The Biochemical Basis of Life”. This six day conference featured an exciting and diverse program with internationally renowned speakers that are at the forefront of their fields. Topics covered included Mechanisms of Gene Expression; Membranes, Receptors & Bioenergetics; Structural Biology & Biophysics; Systems Biology, Bioinformatics & Theoretical Biology; Molecular Neuroscience; and From Chemical Biology to Molecular Medicine. To coincide with this FEBS meeting, Portland Press highlights a collection of recent papers.
This collection of papers covers a wide range of topics including insulin sensitivity, fatty acid and glucose oxidation, lipid metabolism, diabetes and investigating the clinical effects of obesity. The Editorial Board of Clinical Science are are pleased to invite the submission of original research articles on obesity and co-morbidities in a call for papers for the journal, for more information see our website here.
Mitochondria play an essential role in oxidative phosphorylation and energy production, and also function in cell signalling and the cell death machinery. This Collection from Portland Press includes high-quality papers concerning various aspects in the field of mitochondrial biology that have been published in our family of journals.
Since the recognition of miRNAs as important biological regulators, research has revealed many different sets of miRNAs and multiple roles for miRNAs in many varied biological processes. This Collection from Portland Press includes high-quality papers concerning various aspects in the field of miRNA biology that have been published in our family of journals.
This collection of papers highlights recent advances in the study of biochemistry and molecular medicine in relation to NADPH oxidase, a major cause of atherosclerosis. This virtual issue of Clinical Science includes commissioned papers and research submitted in response to our 2014 call for papers.
This Collection from Clinical Science highlights a selection of recently published high-quality papers on various aspects of kidney health and disease, including diabetic nephropathy, inflammatory kidney disease and chronic kidney disease.